Galena is the largest city in and the county seat of Jo Daviess County, Illinois, with a population of 3,429 at the 2010 census. A 581-acre section of the city is listed on the National Register of Historic Places as the Galena Historic District. The city is named for the mineral galena, which was mined by Native Americans in the area for over a thousand years. Owing to these deposits, Galena was the site of the first major mineral rush in the United States. The first American settler arrived in 1821, and by 1828, the population was estimated at 10,000, rivaling the population of Chicago at the time. The city emerged as the largest steamboat hub on the Mississippi River north of St. Louis, Missouri. Galena was the home of Ulysses S. Grant and eight other Civil War generals. Today, the city is a tourist destination known for its history, architecture, and resorts.